Vol. 8, Issue 4 (2019)

Author(s):
KV Tsemenko, IV Kireev, MА Komissarenko and OM Koshovyi

Abstract:
The aim of the work was to study the analgesic activity of the phytosubstance from the complex of cowberry with arginine in a single intragastric administration. The study object was a modified phytosubstance, a complex of phenolic compounds of Vaccinium vitis-idaea leaves with arginine. The analgesic activity was studied on the model of acute thermal pain, which was modeled in a conventional behavioral hot plate test to study the pain sensitivity and the analgesic effect of pharmacological drugs. The appearance of a powerful analgesic effect of the complex of cowberry with arginine can be explained by addition of arginine to the phytosubstance studied, while the removal of the amino acid arginine from the phytosubstance was manifested by a decrease in the analgesic effect by 94% in 30 min, on average by 52% in 60 and 120 min and by 34% in 180 and 240 min after administration of the phytoextract from Vaccinium vitis-idaea leaves extracted with 50% ethyl alcohol compared to the group animals receiving the complex of cowberry with arginine. The amino acid arginine itself had no analgesic effect at all compared to the control group.