Vol. 8, Issue 4 (2019)

Author(s):
Sumit Sarkar, Anindya Bagchi, Anusree Raha, Prosenjit Mukherjee, Monit Paul, Sourav Roy and Rahaman Mehedi Mamud

Abstract:
Haemostasis is the process of forming clots in the walls of damaged blood vessels to prevent abnormal bleeding and to maintain intravascular blood in a fluid state. There is an increasing need to source for pharmacological and medicinal materials from plant source. We aimed to study the possible coagulation effect of Datura flower extract and methanol extracts in vitro anticoagulant activity by using blood samples of poultry bird. In vitro coagulation effects of Datura extract in different concentrations 100, 125 and 250 microliter were examined in the blood samples of poultry bird by measuring prothrombin time (PT). The both extracts were found to inhibit coagulation process and significantly prolonged prothrombin time in a dose-dependent manner. The principle involved in this extracts in different concentrations inhibits clot formation and increases prothrombin time. This also subject to further studies on efficacy and safety, it can well be used, in the future, as a supplementary anticoagulant agent in cardio problems.