Vol. 8, Issue 4 (2019)

Author(s):
Alka N Choudhary and Suhasini Nayal

Abstract:
Therapeutic effectiveness of a drug depends upon the bioavailability and solubility of drug molecules. Solubility plays very important role to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Currently only 8% of new drug candidates have both high solubility and permeability. Due to advanced research and development, there are varieties of new drugs and their derivatives are available. But more than 40% of lipophilic drug candidates fail to reach market due to poor bioavailability, even though these drugs might exhibit potential pharmacodynamic activities. The lipophilic drug that reaches market requires a high dose to attain proper pharmacological action. Hydrotropy is a unique solubilization technique used to describe the increase in the solubility of a solute by the addition of a large amount of second solute results in an increase in the aqueous solubility of another solute.