Vol. 8, Issue 5 (2019)

Author(s):
Feshchenko HI, Oleshchuk OM, Marchyshyn SM and Nakonechna SS

Abstract:
For the treatment of gastric ulcer and duodenal ulcer, a number of drugs is used with a wide range of effects - anti-inflammatory, reparative, analgesic, hemostatic activities. Considering that most of them are synthetic with a significant number of side effects and a number of contraindications, the alternative is to search for new drugs, including plant origin. A well-known medicinal plant rosebay willowherb (Chamaenerionangustifolium L.), which contains a significant amount of phenolic compounds (tannins, flavonoids, hydroxycinnamic acids) is an object of interest. According to the literature, it is used in traditional medicine for treatment of gastric ulcer. It was experimentally established that lyophilized extract of rosebay willow at dose 20 mg/kg proved a significant gastroprotective effect in model of simulated erosive and haemorrhagic gastric mucosa damage caused by acetylsalicylic acid. In cases of administration of lyophilized extract of rosebay willow, the severity of inflammation of gastric mucosa of the rats reduced as well as the intensity of the lipid peroxidation processes up to the physiological level, the reduced glutathione pool and the energy balance of gastric cells restored. Moreover, for this model the investigated extract proved to have a normalization effect on the parameters of coagulation link of haemostasis that confirmed the expediency of the use of lyophilized extract of rosebay willow in concomitant therapy for prevention of haemorrhage in cases of gastro duodenalulcers.