Vol. 8, Issue 6 (2019)

Author(s):
A Suresh, V Chinnasamy and S Anbu

Abstract:
Alcoholism is a growing medical and public health issue both in adults and in the younger generation. Moderate consumption of alcohol is medically beneficial and socially acceptable. However, chronic consumption of alcohol leads to a complex of health problem to human. The present study was carried to evaluate the effect of grape leaf extract (GLEt) on antioxidant and lipid profile states in liver of alcohol induced toxicity. In-vivo administration of ethanol (7.9 g/kg bw/day) for 45 days resulted a significant elevation in the levels of lipid profile in plasma and tissues and significantly lower activity of non enzymic antioxidants (vitamin E, vitamin C and GSH) in liver as compared with control rats. Administration of ethanol along with GLEt significantly decreased elevation in the levels of cholesterol, free fatty acid, triglycerides and phospholipids and improving non enzymatic antioxidants activities in plasma and tissue towards near normal level.