Vol. 8, Issue 6 (2019)

Author(s):
RS Rajasree, P Sibi Ittiyavirah and Jyoti Harindran

Abstract:
Cucumis melo; Linn, family: Cucurbitaceae, (Commonly known as Musk melon or sweet melon) is an annual creeper or climber, cultivated in various parts of the world including India for its edible fruits. The fruits are reported to have several benefits. They act as tonic, laxative, galactagogue, diuretic, strengthens the heart, the brain. In the current study, we evaluated the antiinflammatory potential of the methanol extract of whole fruit of Cucumis melo. The anti-inflammatory effects of various extracts of the fruits of this plant are already evaluated. The present study was aimed to explore some of the mechanism contributing to the anti-inflammatory activity of Cucumis melo, (F1 hybrid). We observed that the extract can inhibit trypsin, as well as the proinflammatory enzymes like cyclooxygenase and lipoxygenase in vitro (P<0.001). The extract also possess stabilizing potential on erythrocyte membrane in vitro. We also evaluated the potential to inhibit thermal degradation of proteins in vitro, but it was found to be in significant.