Vol. 8, Issue 6 (2019)

Author(s):
GV Osyodlo and SA Bychkova

Abstract:
The objective of the work is to determine the leading extraesophageal symptoms, disturbance of spirometric indices and changes in the immune system in patients with GERD and in case of comorbid course with COPD. 98 male patients were examined, who were divided into three groups. 1 group (34 patients) consisted of GERD patients, who had extraesophageal bronchopulmonary manifestations; 2 group consisted of 32 patients with first time COPD; and 3 group consisted of 32 patients with the combination of COPD and GERD. It was determined, that GERD is a multiple-symptom disease, which is characterized by extraesophageal manifestations. Bronchopulmonary manifestations of GERD are a cough syndrome characterized by the presence of a non-intensive, unproductive cough with a small amount of mucous sputum and is combined, in most cases, with the hoarseness of the voice. Cough syndrome during GERD is characterized by a lack of obstructive changes in the study of indicators of external respiration and elevated levels of proinflammatory cytokines in the blood serum. The combined course of GERD and COPD is characterized by the development of intense cough with expectoration, combined with obstructive changes in the indicators of the external respiration, and is characterized by more active proinflammatory changes in the immune system with elevated serum levels such as TNF-α, IL1-β and IFNγ.