Vol. 8, Issue 8 (2019)

Author(s):
Dola LL, Lakatosh VP, Antoniuk MI and Lakatosh PV

Abstract:
Data on the role of systemic and local immunity factors that may contribute to the persistence of the human papillomavirus (HPV) in women with latent papillomavirus infection (PVI) of the uterine cervix (UC) are represented in the work. 210 women with PVI were included into the study, of them – 70 women after 6 months had HPV in UC (persistent PVI), the remaining patients were included into the comparison group (transient PVI). The control group consisted of 15 healthy women. Data analysis showed that women with persistent form of latent PVI were characterized by significantly lowered indexes in terms of control of phagocytic neutrophil response, induced NBTR-test of neutrophils and monocytes and monocytes’ functional reserve; a significant increase in the percentage of cytotoxic lymphocytes (CD8⁺), a decrease in the immunoregulatory index of CD4⁺/CD8⁺ and serum IgA level; while the number of T-lymphocytes, T-helper cells and natural killers were lowered relative to the norm, but no significant differences were recorded. The state of local immunity in women with persistent PVI differed from the control values ​​with a significantly increased level of sIgA (2.3-fold), IL-10 (2.2-fold), g-IFN (1.6-fold), and also a low content in the cervical section of the TNF-a and IFN-a (1.3-fold and 1.1-fold, p>0.05).