Vol. 8, Issue 9 (2019)

Author(s):
Aparna Reddy N, Eswara Prasad P, Padmaja K, Adilaxmamma K, Alpha Raj M, Muralidhar Y and Prasad TNKV

Abstract:
Green plants possess a variety of bioactive constituents like alkaloids, flavonoids, tannins, terpenoids and saponins which possess wound healing properties. The reducing properties of the bioactive constituents have been exploited in the synthesis of silver nanoparticles. The aim of present study was to evaluate the wound healing properties of B. ovalifoliolata ethanolic extract mediated silver nanoparticles (BENS) in comparison with 1% povidone iodine, citrate coated silver nanoparticles (AgNPs) and B. ovalifoliolata ethanolic extract (BE). The wound healing activity was evaluated in three wound models i.e., excision, incision and dead space wound model. The topical application of BENS showed better wound healing properties as evidenced by higher wound breaking strength, complete re-epithelialization with regrowth of hair. BENS promoted wound healing by improving angiogenesis, collagen production and fibroblast proliferation and by reducing oxidative stress. Further a significant increase in biochemical parameters viz, hydroxyproline, hexosamine, protein content and antioxidant parameters viz, catalase and vitamin C confirmed its wound healing potential. The present study showed that B. ovalifoliolata can be successfully used for the synthesis of nanoparticles and this phytogenic nanosilver could be a better option in wound management.