Vol. 8, Issue 11 (2019)

Author(s):
Vamsee Krishna Reddy K, Madhusudhan Raju R and Maneshwar T

Abstract:
Novel Chalcones is considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Traditionally, chalcones are prepared by Claisen-Schmidt condensation. The structures of the newly synthesized compounds (3a-3o) were elucidated by IR, 1H-NMR, Mass spectroscopy. All the synthesized compounds (3a-3o) screened for their anti-bacterial activity and anti-inflammatory. Anti bacterial activity of 3b, 3c, 3i and 3o showed more activity and 3d, 3j, 3m and 3n showed less activity when compare with streptomycin. From anti-inflammatory evaluations, dose level of 50mg/kg of test compounds reported significantly higher activity when compared to dose level of 20 mg/kg. Moreover, compound 3d, 3g, 3j and 3o resulted in similar anti-inflammatory activity when compared with Celecoxib.