Vol. 9, Issue 2 (2020)

Author(s):
Robin, Vivek, Vikas and SK Jain

Abstract:
Pyrethroid insecticides are used over organochlorine and organophosphates due to their high effectiveness, low toxicity to non-target organisms and low biodegradability. The combined exposure of cypermethrin and deltamethrin was given in adult male Wistar rats. Various biochemical and oxidative stress parameters were analysed up to 14 days and their amelioration by Withania somnifera and resveratrol was investigated. Cypermethrin and deltamethrin was given orally at rate of 75mg/kg and 4mg/kg body weight in adult male Wistar rats. The combined exposure of cypermethrin and deltamethrin caused significant increase in ALT, AST, GGT, BUN, creatinine, lipid peroxidation (MDA) while it caused decrease in tissue protein level and antioxidants level viz. reduced glutathione in rats. In cypermethrin plus deltamethrin plus Withania somnifera group and cypermethrin plus deltamethrin plus resveratrol group, both Withania somnifera and resveratrol co-treatment restored the changes to normal observed following combined cypermethrin and deltamethrin exposure in rats. The present study showed that combined cypermethrin and deltamethrin exposure cause biochemical alterations and oxidative stress in rats which is reversed and restored to normal values following co-treatment with Withania somnifera and resveratrol. This indicates the ameliorating effect in rats exposed to cypermethrin and deltamethrin combination.