Vol. 9, Issue 2 (2020)

Author(s):
Vivek, Robin and SK Jain

Abstract:
This experiment was conducted to evaluate the ameliorating effect of resveratrol against induced histopathological changes by thiacloprid in rats. Thiacloprid, a neonicotinoid insecticide is known to target the nicotinic acetyl choline receptors (nACHRs) in insects and potentially in mammals. The aim was to investigate the effect of acute (24 h) and subacute (28 days) toxicity of thiacloprid and its amelioration by resveratrol in male Wistar rats. Histopathological alterations were observed in kidney, liver, brain and spleen in both acute and subacute studies due to thiacloprid exposure which were attenuated by resveratrol co-treatment. The study revealed that thiacloprid possesses mild to moderate toxicity potential for hepatic, renal, spleen and CNS of adult male rats. Resveratrol possesses potential to sufficiently ameliorate the toxicity produced by thiacloprid and as such do not have any toxic effect at therapeutic doses in adult male wistar rats.