Vol. 9, Issue 3 (2020)

Author(s):
T Rajendrakumar, Suguna Rao, ML Satyanarayana, HD Narayanaswam, SM Byregowda and KM Purushotham

Abstract:
The role of ethanolic extract of Andrographis paniculata [AP], in preventing cisplatin [CP] induced oxidative damage in rat kidney was studied. Sixty Wistar Albino rats were divided into five groups with twelve rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III served as AP control and were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP fifteen days prior to CP administration and followed by AP treatment for 45 days. Rats in group V were administered with CP and concurrently treated with AP extract at 500mg/kg by oral gavaging for 45 days. The kidney samples collected at 7^th, 14^th, 28^th, and 45^th day of the study were subjected for estimation of catalase, superoxide dismutase, glutathione peroxidase and malondialdehyde [MDA]. Significant decrease [P<0.05] in the levels of antioxidant enzymes and increase in MDA levels were recorded in CP treatment group. The AP treatment groups revealed a significant recovery [P<0.05] all enzymes and decrease in MDA levels which suggested that AP has a good antioxidant effect and could be effectively used for prevention of toxic side effects of CP. The study also indicated that pre-treatment of AP prior to CP administration has good prophylactic effect.