Vol. 9, Issue 3 (2020)

Author(s):
Priya Tiwari

Abstract:
Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been introduced extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their specified degree of biocompatibility, biodegradability and a series of other potential advantages. Carrier erythrocytes have been evaluated in thousands of drug administration in humans proving safety and efficacy of the treatments. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biological, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. Erythrocytes mediated drug delivery has been reported with therapeutic enzymes and antiviral agents to maximize therapeutic performance, reduce the side effects, as circulating depots for controlled drug release, drug targeting, treatment of parasitic diseases, hepatic tumors, removal of toxic agents etc. In this review, isolation of carrier erythrocytes, methods of drug loading, methods and clinical applications of resealed erythrocytes were presented.