Vol. 9, Issue 3 (2020)

Author(s):
Sindhu Jose, T Sivakkumar and R Ramprasad

Abstract:
Traditional medicinal plants have been used in the treatment of various diseases for centuries. A number of plant-derived compounds have been proposed as anticancer agents and are currently undergoing medical development. Begonia trichocarpa Dalz of Begoniacae family is wild, vulnerable, endemic species found in Kerala. Therefore, in this study, Methanol extract of Begonia trichocarpa (MEBT) was investigated for the apoptotic effect on human cervical cancer cells (HeLa). The In vitro anti-proliferative effect of MEBT on cultured HeLa cells was performed by colorimetric MTT assay. It was assessed that MEBT has anti proliferative effect on cultured HeLa cells and the IC₅₀ value was found 24.05µg/ml. Anti-proliferative effect of methanol extract exhibited 84.06% inhibition at 100µg/ml concentration, whereas fraction BGTM1 from methanol extract of Begoina trchocarpa Dalz showed its anti-proliferative effect 56.65 % at 100µg/ml concentrations on cultured HeLa cells.