Vol. 9, Issue 6 (2020)

Author(s):
Amrita Parle and Nitish Kumar

Abstract:
In the present study a series of novel 3-acetylindole derivatives were synthesized by reacting 3-acetylindole and benzaldehyde. The synthesized 3-acetylindole derivatives were characterized physicochemically, by elemental analysis and spectral (IR and ¹H-NMR) analysis. The synthesized compounds were screened for their in-vitro antifungal activity against Candida albicans, Rhizopus oligosporus, Gibberella fuzikuroi and Asperigillus niger by cup plate method. The results revealed that five compounds namely NK-3, NK-8, NK-11, NK-13 and NK-14 have better or equal antifungal activity compared to the standard fluconazole.