Vol. 10, Issue 1 (2021)

Author(s):
Mitek Tarang, Pushpendra Kumar, BL Saini, Snehasmita Panda, Sachin Tripura, Supriya Chhotaray and Aamir Bashir Wara

Abstract:
Laboratory mice have been widely utilized in various biological researches worldwide due to their high degree of homology with humans. Inbred and outbred strains of mice are the two major classes of laboratory mice. Microsatellites remain highly informative and useful measures of genomic variation for linkage and association studies. The objective of this study was to investigate the association of microsatellites polymorphism with body weight in two different generations of Swiss albino mice population. Body weight (BW) was recorded individually for all the mice when mice from each generation reached at the age of around 2 and half months. The association with the body weights was evaluated by using ten microsatellites markers. All the microsatellite markers were found to be polymorphic. Effect of allelic variants of microsatellites (genotype) was determined on BW through PROC GLM module of SAS. The result reveals that two microsatellite loci (D9Mit27 and D10Mit180) showed a significant association with body weight of the mice. Although the present study should be considered preliminary, our results reveal for the first time that two microsatellite loci were associated with body weight traits in mice.