Vol. 9, Issue 12 (2020)

Author(s):
Manish Kumar Verma, AH Ahmad, Disha Pant, Parul Rawat and Neeraj Kumar

Abstract:
Cyclophosphamide (CYP) is one of the commonly used anticancer drugs, but its use is limited by hematologic toxicity. Chenopodium album passing hepatoprotective, gastroprotective, cardioprotective, anti-inflammatory, and renal protective potential but its myeloprotective potential is underexplored. The aim of this study was to evaluate the ameliorative effect of Chenopodium album in cyclophosphamide-induced oxidative stress and hematologic toxicity in albino rats. CAHE @ 400 mg/kg body weight, po daily for 28 days and Cyclophosphamide @ 100 mg/kg body weight, po on 9th and 16th day given alone and with a combination of both in rats. At the end of the experiment, animals were humanly killed, and blood and liver samples were collected and stored for hematologic, and oxidative stress marker level estimations. Hematologic findings revealed hemoglobin and lymphocyte increases significantly (P<0.05) by the treatment of CAHE treatment significantly ameliorated oxidative stress parameter level. Treatment with CAHE significantly (P<0.05) reversed the hematologic toxicity and oxidative stress. However, more detailed studies are needed to explicate the mechanism underlying its protective effect.