Vol. 9, Issue 12 (2020)

Author(s):
Sunena Jha and Pawan Jalwal

Abstract:
Migraine is among most prevalent neurological disorders. Effective drug delivery to brain is first preference to treat neurological disorders. Most of the antimigraine drug used presently suffered with poor bioavailability and slow onset of action by oral route. Various approaches are utilized for drug delivery to brain and among all, nose to brain drug delivery is evolved as effective method to circumvent blood brain barrier. Novel intranasal nanoformulations can be a promising approach for direct drug delivery to the brain to treat migraine headache. Recently different types of nanoformulations are developed to improve the brain targeting efficacy by improving drug retention and permeation over the nasal mucosal epithelium. Nanoformulations are designed to avoid different problems, including low solubility, poor bioavailability, slow onset of action, and enzymatic degradation. The present review summarizes the various applications and benefits of nanoformulations used for nose to brain drug delivery of antimigraine drugs.