Vol. 9, Issue 12 (2020)

Author(s):
S Pavithra, SP Preetha, M Thangapandiyan and S Shanmuganathan

Abstract:
5-Fluorouracil (5-FU) is an anticancer drug widely used for the treatment of cancers especially colorectal cancer. In spite of treating cancer, it also causes toxicity to other rapidly dividing cells. The present study was carried out to evaluate the effect of the Fractionated Pectin Powder (FPP) capped nano Zinc oxide (nZnO) in 5-Fluorouracil induced toxicity in haematological of male rats. Experimental rats were divided into four groups (ݑ› = 10) which received normal saline (Group I), 5-FU @20gm/kg b.wt (Group II), FPP capped nZnO @ 40mg/kg b.wt (Group III), 5-FU @20gm/kg b.wt and FPP capped nZnO @ 40mg/kg b.wt (Group IV). All treatments were given orally upto14 days. On 15^th day of sacrifice blood samples was collected after serum separation used for respective analysis. Treatment with FPP capped nZnO significantly. This study highlights the protective role of FPP capped nZnO against 5-FU induced oxidative stress to the testicular and epididymal cells.