Vol. 10, Issue 7 (2021)

Author(s):
Kadudula Aparna, D Madhuri, M Lakshman, B Anilkumar, B Swathi and Y Ravikumar

Abstract:
The amelioration effect of quercetin on Methotrexate induced toxic effect on body weights and haematological parameters were studied in Wistar rats. The experiment was carried on 48 healthy albino Wistar rats (200-220 g) according to the guidelines and prior approval of Animal Ethics Committee. Animals were divided into four groups consisting of 12 in each group. Group1-Control, group 2-Methotrexate treated rats @ 8mg/kg b.wt (i.p) weekly once. Group 3-treated with Methotrexate @ 8mg/kg b.wt, (i.p) weekly once and quercetin @ 80mg/kg b.wt, Orally daily. Group 4-treated with quercetin @ 80mg/kg b.wt, orally daily. The experiment was carried out for a period of 28 days and rats were sacrificed on 14^th and 28^th day of experimental study. Significant (P< 0.05) reduction in b. wts were recorded in group 2 rats. All the Heamatological parameters were significantly reduced in group 2 and significant improvement of all parameters was noticed in ameliorative group (group 3).