Vol. 10, Issue 7 (2021)

Author(s):
Dr. Harshal J Shete, Dr. Santosh D Moregaonkar, Dr. Govind R Gangane, Dr. Anand N Choudhari, Dr. Akshay R Chaure and Dr. Pooja B Kachave

Abstract:
The present experiment was planned to study the sub-acute oral toxicity of profenofos in Gramapriya birds and hepatoprotective effects of T. purpurea in toxicated birds. 100 healthy days old ‘Gramapriya’ chicks randomly distributed into four treatment groups, having 25 chicks each up to 28 days. The birds of control group I was given standard feed and ad libitum of water; groups II were intoxicated daily with a solution of Profenofos @ 1.6 mg/kg body weight through oral gavage; group III were fed with a T. purpurea leaves powder @ 0.1% of feed and group IV was treated with Profenofos @ 1.6 mg/kg body weight daily through oral gavage + T. purpurea leaves powder @ 0.1% of feed daily. Pathological studies including clinical signs, organ weights, gross lesion and histopathological examination in birds of all groups were examined at 0^th 14^th and 28^th day of study. All pathological examinations of birds from Group I and III showed non-significant changes throughout the experiment. On 14^th and 28^th day of experiment, pathological studies and histopathological examination of the sections from birds of group II, showed significant alterations. Efficacy of T. purpurea leaves powder in group IV birds revealed the reduced necrotic changes in the sections of liver, kidney and intestine of birds in group IV as compared to group II birds.