Vol. 8, Issue 5 (2019)

Methods: The chitosan nanoparticles of terbinafine Hydrochloride was prepared by modified ionic gelation method and optimized by using Box-Behnken Design. The optimized nanoparticles formulation further characterized for the particle size, percentage drug encapsulation efficiency, percentage yield and mucoadhesive strength. The drug permeation behavior of the optimized formulation was studied by using Franz diffusion cell using goat skin and compared with marketed formulation.

Results and conclusion: The nanoparticles size below 100nm was prepared successfully by modified ionic gelation method. The low flux value of terbinafine HCl mucoadhesive nanoparticles as compared to drug suspension and marketed formulation revealed that the nanoparticles permeated through goat skin mucosa in a controlled manner up to 24 hrs, whereas terbinafine suspension and marketed formulation show high permeability over short duration. Thus topical delivery of terbinafine hydrochloride nanoparticles is an efficient tool to improve its bioavailability and therapeutic effect against fungal infections.