Vol. 10, Issue 12 (2021)

Author(s):
Poonam Gupta and Ajet Saxena

Abstract:
Valacyclovir Hydrochloride has the chemical name L-valine -2-[(2-amino-1,6-dihydro-6-oxo-9-H-purin-9-yl-) methoxy] ethyl ester monohydrochloride, is prodrug and the ester derivative of acyclovir, a purine nucleoside analogue, useful in the treatment of anti-viral infections. European pharmacopeia related substances C, D, F, H, I, J, P and O and others impurities have been obtained during its synthesis. The present work describes the detection, origin, synthesis, characterization of some related substances, which may improve the commercial process.