Vol. 11, Special Issue 1 (2022)

Author(s):
Dinesh MB, SK Sharma, JS Lamba, MM Lonare and Dr. SK Singh

Abstract:
Marbofloxacin is a third generation broad spectrum fluoroquinolone developed exclusively for use in veterinary medicine against many pathogens of veterinary importance. NSAIDs are the most commonly used group of drugs prescribed by physician along with antibiotics. The present study was carried out to investigate the effect of meloxicam administration on the disposition of marbofloxacin at single dose i.e 8 mg.kg^-1 in 6 months - 1 year old buffalo calves. Meloxicam (0.5 mg.kg^-1) was administered intramuscularly followed by marbofloxacin at 8 mg.kg^-1 i.m to the buffalo calves. The concentration of marbofloxacin in plasma was estimated using HPLC. The plasma concentration was maintained upto 12 h. Vd_area of marbofloxacin was found to be 8.7 ± 1.50 L.kg^-1 indicating good tissue distribution. The values of C_max, t_max AUC_0-∞ and AUMC found to be 1.19 ± 0.07 µ.g.ml^-1, 1.00 h, 6.11 ± 0.60 µg.ml^-1.h and 29.26 ± 2.73 µg.ml^-1.h² respectively. The t_1/2β, Cl_B and MRT found to be 4.37 ± 0.28 h, 1.34 ± 0.12 L.kg^-1.h^-1 and 4.64 ± 0.2 h respectively. The selected dose of marbofloxacin (8 mg.kg^-1) administered i.m, along with meloxicam (0.5 mg.kg^-1) in buffalo calves was found effective against MIC value ≤ 0.073 µg.ml^-1. Meloxicam seems to affect the pharmacokinetic behavior of marbofloxacin remarkably.