Vol. 11, Special Issue 1 (2022)

Author(s):
Dishant Aggarwal, Vinod Dumka, Simratpal Saini and Manjinder Sharma

Abstract:
Among Pesticides, Abamectin are used worldwide as antiparasitic drug in agriculture as well as veterinary medicines and also shows potential harmful effects. Therefore, the present study was conducted to seen the undesirable effects of exposure to sub-acute toxicity of abamectin (2 mg/kg bw) in female rats for 28 days on neurobehavioral, biochemical and antioxidant activity changes. A hydro-alcoholic extract of Aegle marmelos leaves were also tested for its potential to reduce pesticide poisoning. Results showed that marked and significant anxiolytic activity is seen by leaf extract against abamectin induced rats which showed anxiogenic activity. The serum levels of Alanine and Aspartate aminotransferase, Blood urea nitrogen and creatinine is significantly reduced as compared to Abamectin-induced rats, while elevation in total protein was observed. Exposure to abamectin significantly decrease the Superoxide dismutase activity, while show no significantly effect on catalase, reduced glutathione and lipid peroxidation antioxidant activity. Aegle marmelos leaves treated rats with abamectin showed marked improvements in antioxidant activity, indicating that Aegle marmelos extract bear a potent anxiolytic, hepatoprotective, nephroprotective and antioxidant activity. As a result, the subsequent leaf extract of Aegle marmelos as herbal medicine may be advantageous for individuals with liver and kidney impairment, as well as for reversing the damage caused by abamectin exposure.