Vol. 11, Special Issue 3 (2022)

Author(s):
Prashantkumar Waghe, Prakash Nadoor, Vijaykumar M, Sunilchandra U, Rashmi Rajashekaraiah and Pavithra BH

Abstract:
The present study aimed to evaluate the modulatory role of sub-acute exposure to sodium (meta) arsenite on pharmacodynamic, viz., antinociceptive, anti-inflammatory, and antipyretic responses mediated by meloxicam in Wistar rats. Rats were divided randomly into 5 groups (n=6). Control rats were given distilled water (Group I). Group II was maintained as Group I but was given meloxicam (2 mg/kg b. wt.) on the 29th day. Groups III, IV, and V rats were given arsenic through drinking water at 0.5, 5.0, and 50 ppm, respectively, for 28 days and meloxicam (2 mg/kg b. wt.) was administered the next day (29th day). For assessment of antipyretic effects, one more additional group (Group VI) was taken and given LPS @ 1.8 mg/kg b. wt. for induction of pyrexia (LPS control). Pain and inflammation were carried out by using formalin-induced nociception and carrageenan-induced inflammatory model(s), respectively by using a standard protocol. The study revealed that experimental rats exposed to higher doses of arsenic showed inhibition of meloxicam-mediated antinociceptive, anti-inflammatory, and antipyretic responses. Further, meloxicam inhibited the arsenic-induced elevation of interleukin-1β, interleukin -6, tumor necrosis factor-α, and COX2 mediated prostaglandin E2 in the hind paw muscle. The results intimate that the therapeutic activity of meloxicam unaltered by the presence of arsenic in drinking water within a defined limit, but can interfere the pharmacodynamic when its concentration when relatively high (50ppm). Thus, the observation made has clinical relevance in situations where man and animals are exposed to arsenite epidemic- geographical locations