Vol. 11, Special Issue 4 (2022)

Author(s):
Anurag Semwal, Akansha Khati, Avdhesh Kumar, Mahendra Kumar Yadav and Diksha Arya

Abstract:
In nature, antimicrobial peptides (AMPs) are widely involved in the innate host defense. Fish are considered as an great source of antimicrobial peptides because they represent all the major AMP classes, including cathelicidins, hepcidins, defensins, histone-derived peptides, and piscidins. Antimicrobial peptides (AMPs) are said to be highly promising as natural alternative to chemical antibiotics. The fish peptides exhibit broad-spectrum antimicrobial action, killing both fish and human pathogens. Moreover, they are immunomodulatory, and their genes are highly reactive against microbes and innate immuno-stimulatory molecules. Later research has illustrated that some of the special properties of fish peptides, including their ability to act even in very high salt concentrations, make them good potential targets for development as therapeutic antimicrobials. AMPs have demonstrated diverse biologic effects, like endotoxin neutralization, immunomodulating activity and induction of angiogenesis.