Vol. 11, Special Issue 6 (2022)

Author(s):
Akudari Anusha, K Venkata Ramana, K Chandra Shekar Reddy and B Swathi

Abstract:
The Canine Transmissible Venereal Tumour (TVT) is a specific neoplastic tumour commonly found in canines. It is usually malignant and transplantable tumour most often spread through sexual intercourse, by living cancer cells. Which mainly affects external genitalia of the male and female dogs. CTVT case was diagnosed based on the gross lesions, anatomical location, cytology and impression smears of the tumour were done. Tumour cytology showed cytoplasm of the cells was blue in colour with many clear distinct cytoplasmic vacuoles. In the present study, Group I dogs were administered with 1 ml of normal saline as control group considered to establish normal values. Group II dogs were treated with Injection Vincristine @ 0.5 mg/m2 or 0.025 mg/kg b.wt administered I/V once in a week for 4 to 6 weeks. Appreciable tumour regression was noticed within four to six weeks. Four dogs (66.66%) showed complete cure by the fourth dose itself. Dogs receiving Vincristine sulphate develops anaemia and leukopenia, animals showed vomiting and diarrhoea. In some, drug resistance was noticed leading to delay in the reduction of tumour mass and to combat the problem of drug resistance Ivermectin an antineoplastic agent was used along with Vincristine. Group III dogs were treated with Vincristine @0.025 mg/kg b.wt once in a week and Ivermectin 500 mcg per kg body weight S/C at 2 weeks Interval. 5 dogs showed (83.33%) complete clinical regression of the tumour just after 2 weeks of chemotherapy, Number of treatment cycles required for complete disappearance of the tumour was less. In some CTVT cases drug resistance was noticed leading to delay in reduction of tumour masses, to combat problem of drug resistance Ivermectin an antineoplastic agent was used along with Vincristine. Group IV were treated with Vincristine @0.025 mg/kg b.wt and Ivermectin 200 mcg per kg b.wt S/C at 2 weeks interval animals showed clinical improvement after 3week of chemotherapy after one dose of vincristine. Side effects like vomiting and alopecia were observed in 3 animals after 2nd dose.