Vol. 11, Special Issue 7 (2022)

Author(s):
KD Thakor, DV Joshi, SH Raval, PB Rathod, PI Sindhi, TR Kumbhani, JG Patel and BJ Patel

Abstract:
The present study on toxicopathology of tartrazine was carried out on 80 Wistar rats comprised of 40 male and 40 female divided into four equal groups, viz., Groups I, II, III and IV. Group I served as control and received distilled water, while Groups II, III and IV received tartrazine @ 50, 100, 200 mg/kg body weight orally dissolved in drinking water for 90 days, respectively. The experimental animals were closely observed daily for clinical and behavioural changes and weekly for body weight. All rats were subjected to haemato-biochemical alterations and organ weight studies on 91st day of experiment. The daily observation of animals for clinical and behavioural signs as well as weekly body weights revealed no significant change in treatment groups throughout the experimental period of 90 days as compared to control. The haematological parameters revealed significant (P<0.05) increase in the values of lymphocytes and decrease in neutrophils value of all treatment group of both sex. No any significant change was recorded in any other haematological parameters in any of the treatment groups. The biochemical parameters revealed significant (P<0.05) increase in ALT, AST, ALP and GGT value of all treatment groups of both sex, whereas, total protein values showed significant (P<0.05) increase only in female treatment groups.