Vol. 11, Special Issue 7 (2022)

Author(s):
Jyoti Choudhary, Nareshi Meena, Mahendra Milind, Taruna Bhati and BN Shringi

Abstract:
Toll-like receptors (TLRs) are important for raising innate immune responses in both invertebrates and vertebrates. TLRs in fishes, birds and mammals have been evolving under positive selection. However, relatively lack of knowledge for the dromedary camel TLRs, compared to that available for the human or other animal. It is essential to understand the structural and functional aspect of camel TLRs. The present work deals with the use of bioinformatics to describe the physiochemical properties of TLR4-TLR10 from obtained sequences which were based on gene bank of NCBI. GRAVY (grand average of hydropathicity) demonstrated the hydrophilic nature of these proteins. The computed instability index represented the stable nature of the proteins of TLR 5, 6, 7 and 10. All proteins were acidic in nature except TLR 9. Our findings provide a chemical and structural basis for optimizing the adjuvant design to elicit broad-based antibody and T cell responses with protein antigens.