Vol. 11, Special Issue 7 (2022)

Author(s):
Renu, Shobha Burdak, H Dadhich, M Mathur, PK Boyal, M Mehra, R Poonia and Rajesh Mohta

Abstract:
Clostridium perfringens type D infection is an acute toxaemic fatal disease of sheep of all ages and is recognized worldwide. The present study was conducted to describe the gross and histopathological changes observed in Clostridium perfringens type D infection in sheep. In the present investigation, a detailed necropsy was performed on 362 sheep irrespective of age, sex and breeds. Out of these, 66 sheep found positive on the basis of gross and histopathological examination of carcasses. Grossly, kidneys were swollen, darkly congested, and appeared soft and pulpy in consistency. Liver was haemorrhagic. Heart showed haemorrhages, and congestion. Microscopically, kidneys showed degenerative, necrotic and iniflammatory changes. Focal coagulative necrosis of hepatocytes was seen in liver. Massive infiltration of mononuclear cells and polymorphonuclear cells was seen around the central vein. Liver revealed fatty changes, edema, and congestion in sinusoidal space. Sections of heart showed haemorrhages between the myocardial fibres. Some of sections showed congestion and mononuclear and polymorphonuclear cells infiltration in between the cardiac muscle fibres with separation of myocardial fibres.