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Vol. 11, Special Issue 7 (2022)

Comparative studies on medetomidine and dexmedetomidine as pre-anaesthetics for propofol-isoflurane general anesthesia in dogs

Author(s):
Dr. Ramesha H, Dr. Mahesh V, Dr. Nagaraja BN, Dr. Sudha G, Dr. Ranganath L and Dr. Srinivasa Murthy KM
Abstract:
The research was conducted in 18 clinical cases presented to Department of Veterinary Surgery and Radiology, Veterinary College Hospital, Hebbal, Bengaluru. Animals were randomly divided into three groups viz., Group I, Group II and Group III consisting of six dogs in each group. Dogs of all the groups were atropinised (@0.04 mg/kg) subcutaneously except Group I dogs. Dogs in Group I directly induced with propofol (@6mg/kg) intravenously. In dogs of Group II Medetomidine was administered @ 20mcg/kg IV, ten minutes later the anesthesia was induced by administering Propofol @ 3 mg/kg IV. In dogs of Group II Dexmedetomidine was administered @ 10mcg/kg IV, ten minutes later the anesthesia was induced by administering Propofol @ 3 mg/kg IV. Maintenance of anesthesia was done by isoflurane in all the three groups. Anaesthetic combinations were evaluated by clinical and physiological observations. The fast onset of sedation was observed in Group II and Group III dogs. The induction time was significantly slower in Group I dogs followed by Group III and Group II dogs. Smooth recovery in Group II and Group III dogs without any side effect. Excellent muscle relaxation and good analgesia were observed in Group II and Group III dogs as compared to Group I. Physiological parameters fluctuated within the normal limits. The anesthetic protocol carried out in Group II and Group III given satisfactory results with respect to sedation, analgesia, muscle relaxation, smooth induction and recovery without any untoward events or complications as compare to directly induced Propofol Group.
Pages: 2047-2051  |  233 Views  112 Downloads
How to cite this article:
Dr. Ramesha H, Dr. Mahesh V, Dr. Nagaraja BN, Dr. Sudha G, Dr. Ranganath L and Dr. Srinivasa Murthy KM. Comparative studies on medetomidine and dexmedetomidine as pre-anaesthetics for propofol-isoflurane general anesthesia in dogs. The Pharma Innovation Journal. 2022; 11(7S): 2047-2051.

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