Vol. 11, Special Issue 7 (2022)

Author(s):
Sumeet Pal, Rukmani Dewangan, Raju Sharda, SK Tiwari, Durga Chaursia, BB Khutey, HK Ratre and PDS Raghuvanshi

Abstract:
The present study was conducted to evaluate the effect on various haematological and biochemical parameters following administration of glycopyrrolate-butorphanol, glycopyrrolate-dexmedetomidine and glycopyrrolate-acepromazine as preanaesthetics to propofol anaesthesia in dog. Eighteen adult dogs of either sex were randomly divided into three groups (BP, DP and AP) with six animals in each group. Ten minutes prior to the anaesthetic administration, dogs were administered with glycopyrrolate @ 0.02 mg/kg b.wt. intramuscularly and animals of group BP, DP and AP were premedicated intramuscularly with butorphanol @ 0.3 mg/kg b.wt., dexmedetomidine @ 10 µg/kg b.wt. and acepromazine @ 0.4 mg/kg b.wt. respectively. General anaesthesia was induced with propofol @ 7 mg/kg b.wt. intravenously. Haematological parameters viz. Hb, PCV, TEC, TLC and DLC and biochemical parameters viz. serum glucose, serum total protein, serum urea nitrogen, serum creatinine, ALT and AST were estimated before sedation (0) and at 30, 60,120 min. and 6 hrs post propofol anaesthesia. Haematological studies revealed a non-significant decrease in Hb, PCV, TEC TLC and DLC following propofol anaesthesia in all the groups. Hyperglycemia was noted in animals of all the groups after propofol anaesthesia. Other biochemical parameters like serum total protein, serum urea nitrogen, serum creatinine and serum enzyme viz, AST and ALT values showed non-significant changes at various time intervals but remained within normal physiological range. Therefore, it can be concluded that glycopyrrolate-butorphanol, glycopyrrolate-dexmedetomidine and glycopyrrolate-acepromazine with propofol combination does not produce any deleterious effect on vital organs and changes remained within physiological limits, thus propofol can be safely used as induction agent in dogs.