Vol. 11, Special Issue 7 (2022)

Author(s):
Tushar Jain, Ashok Kumar, Sandeep Saharan, Sandeep Kumar, Renu Gupta and Vandana Singh

Abstract:
The study was undertaken to evaluate the comparative effects of vincristine and doxorubicin on haemato-biochemical parameters. For this, twelve animals having soft tissue tumours were randomly divided in two groups of six animals each. In group I, chemotherapy with vincristine sulphate at the dose rate of 0.025mg/kg body weight was given at weekly intervals. In group II, chemotherapy with doxorubicin hydrochloride at the dose rate of 1mg/kg body weight was done at weekly intervals. Blood samples were taken before chemotherapy for haemato-biochemical analysis. It was found that both vincristine and doxorubicin cause bone marrow suppression leading to leucocytopenia and neutropenia. Thrombocytosis was found in group I while thrombocytopenia was found in group II. Increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides, alkaline phosphatase (ALP), cholesterol, gamma-glutamyl transferase (GGT), blood urea nitrogen (BUN), creatinine, lactate dehydrogenase (LDH) and creatine kinase (CK) was found in both groups. This shows that both drugs cause hepatotoxicity, nephrotoxicity and cytotoxicity.