Vol. 11, Special Issue 8 (2022)

Author(s):
Biswadeep Behera, N Pazhanivel, S Vairamuthu, P Jalantha and Ganne Venkata Sudhakar Rao

Abstract:
Multinodular liver cirrhosis is a common end stage pathological condition in humans and dogs, mostly results from chronic hepatitis. A carcass of 9 year, male, and Labrador retriever dog was presented for necropsy to the Department of Veterinary Pathology, Madras Veterinary College, TANUVAS, and Chennai. Grossly, the liver was shrunken and showed presence of diffuse, scattered, multiple, variable size yellowish tawny colour nodular growth. The tissue pieces along with mass was collected, fixed and processed routinely by paraffin embedding technique and sections were stained by H&E and Masson’s trichrome stain. Microscopically, tissue section revealed presence of multiple, variable sized islands of hepatocyte separated by bundles of collagen fibers which was infiltrated with lymphocytes, plasma cells and few macrophages. Proliferation of bile ducts were evident in the periportal areas. The collagen fibers was demonstrated by Masson’s trichrome stains. The tissue sections showed positive signals to cytokeratin, vimentin and Ki-67. Based on the gross, microscopical changes and immunohistochemistry, the case was diagnosed as multinodular liver cirrhosis.