Abstract:The world of animals, humans and environment are inter-connected and give rise to a number of benefits as well as a spread in zoonosis and multifactorial chronic diseases. Rapid climate and environmental changes have led to the emergence of infectious and no-infectious disease. For combat the emerging infectious disease and zoonotic threats, one health approach, as the standard approach is gaining attention. One Health is a collaborative, multisectoral, coordinated, and transdisciplinary approach working at the local, regional, national, and global levels with the goal of achieving optimal health outcomes by recognising the interconnection between people, animals, plants, and their shared environment. In India, one health approach in embryonic stage and increasingly gaining importance. Globally, three major international organisations, WHO, WOAH (founded as OIE), and FAO, are working together to prevent and control health risks at the human-animal-ecosystems interface.