Vol. 11, Special Issue 10 (2022)

Clofibric acid (CA) is a hypolipidemic compound and an active derivative substance of clofibrate has been detected in the water bodies all over the world. For Swiss lakes and German rivers, the concentrations of CA in the surface water and from effluents of Sewage treatment plants are 0.551 μg/Land 1.6 μg/L, ground (4 µg/L), surface and drinking waters (0.07–0.27 µg/L) all over the world. Short term toxicological investigation (96 hours) on Labeo rohita fingerlings was studied at different nominal concentrations such as 1, 10 and 100 μg/L. In case of behavioural responses, opercular movement and mucus secretion both increased significantly. The disparity of behaviour in exposed fish became more pronounced with rising CA concentrations, showing a positive correlation with the concentration. Throughout the trial, there were no obvious signs of anomalous behaviour in the fish in the control group. In accordance with enzymatic responses, Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Lactate Dehydrogenase (LDH) levels in all treatments were statistically significant (p <0.05).