Vol. 11, Special Issue 10 (2022)

Author(s):
Archana Kumari, Dr. Preeti Upadhyay, Dr. ML Aggarwal, Dr. Binu Bhat and Dr. Prabhakar Maurya

Abstract:
Medical devices may provide assistance towards the generation of healthy biological tissues as well as due to intervention as a foreign body for long term in biological system, the device can integrate into the adjacent biological tissues over time. To ensure intended functions as well as compliance of all the regulatory requirements, medical devices are subjected to robust biocompatibility testing, biological evaluation, toxicological evaluations so as to avoid any adverse health effects. Embolization procedure is the process of intentional clot formation for occluding blood vessels for therapy purpose. Host related factors like age, nutritional status, body mass index, previous interventions at the treatment site also play a vital role in response to the clinical application. In the present study, effort has been made to understand the local tissue response in the form of skin reaction as erythema and edema after administering liquid embolic system in the subcutaneous tissue. On intracutaneous injection of liquid embolic system in rabbits, no irritation reactions were observed on visual examination and on graded scores of erythema and eschar formation, as well as oedema formation observed till 72 hours of dose administration. It is concluded that the embolic system is non-irritant as it didn’t elicit any signs of local toxicity.