Vol. 11, Special Issue 11 (2022)

Author(s):
Abhay Gupta, K Shrman, Gyansagar Kushwaha and Dr. Gayatri Singh

Abstract:
Traditionally, a number of medicinal plants are used to treat various hepatic disorders, but only few of them have been pharmacologically evaluated for their safety and efficacy. The plant Andrographis paniculata (AP) (Kalmegha) was traditionally used in Indian system of medicine (Ayurveda) for the treatment of various liver and other disorders. In the present study, an attempt was made to substantiate the ethnopharmacological use of A. paniculata in hepatoprotection against the paracetamol-induced hepatotoxicity. In this study, to induce hepatotoxicity, paracetamol was given at the dose rate of 2 g/kg body weight orally to albino rats. Serum levels of alanine transaminase, aspartate aminotransferase, and alkaline phosphatase were used as indicator to evaluate the liver injury. In addition, creatinine, BUN, and blood parameters were also assayed using the standard procedure. Extract of A. paniculata (APE) @ 400 mg/kg bw orally for 7 consecutive days exhibited significant protection of liver against paracetamol induced hepato-toxicity as depicted by normalization of biochemical and haematological parameters after administration of A. paniculata.