Abstract:Proteus is an emerging food borne pathogen having public health significance. P. mirabilis and P. vulgaris are zoonotic human pathogens causes urinary tract infection (UTI), nosocomial infection, wound infection and septicaemia, therefore, a potential threat to public health. The present study was undertaken to detect multi-drug resistant bacteria – P. mirabilis and P. vulgaris from raw milk and meat samples procured for about 4 weeks from 50 different wards of Tirupati, Andhra Pradesh. All the isolates were subjected to 14 antibiotic discs by using standard disk diffusion method. All the isolates of P. mirabilis from milk and meat samples have shown 100% resistance to Tetracycline, Colistin, Erythromycin and Penicillin-G. All the P. vulgaris isolates from milk have shown 100% resistance to Tetracycline, Colistin, Erythromycin, Penicillin-G, Ampicillin and Polymyxin-B. P. vulgaris isolates from meat have shown 100% resistance towards Tetracycline, Colistin, Erythromycin, Penicillin-G, Ampicillin and Vancomycin. All the isolates of P. mirabilis and P. vulgaris have shown sensitivity to Gentamicin.