Vol. 12, Special Issue 7 (2023)

We examined the influence of histocompatibility on the outcome of infection of Layer CARI-Priya strain with Rous Sarcoma Virus (RSV). Before inoculation, we conducted genomic analysis of the virus using ALV AE(326bp), ALV A(229bp), and MDV(583bp) primers. The introduction of RSV-A into CARI-Priya chicks resulted in the development of tumours with progressive or regressive phenotypes, exhibiting varying tumour profile index (TPI). A considerable increase in TPI scores (5 or 6) in a subset of chicks revealed their vulnerability to RSV-A. 90% of the chicks had metastatic disease, which was a mixture of Myxosarcoma and fibro sarcoma.