Vol. 12, Special Issue 7 (2023)

Author(s):
Dr. Abhay Gupta, Dr. K Shrman, Dr. Gyansagar Kushwaha, Dr. Giriraj Goyal, Dr. Gayatri Singh and Dr. Md Sahil Mansoori

Abstract:
Paracetamol overdose is a common cause of liver injury. Silymarin is a hepatoprotective agent widely used for the treatment of liver injuries of different origins. In order to evaluate the possible beneficial effects of silymarin, albino rats were pre-treated with silymarin (100 mg/kg b.wt. per os) once daily for seven days. On the 8^th day of the experiment, in 24 hour fasted rats, paracetamol was given at the dose rate of 2 g/kg body weight. Paracetamol produced a significant effect on the liver, which was evidenced by an increased level of AST and ALT. The adverse effect of paracetamol was also observed in the kidney, as evidenced by an increased level of BUN and serum creatinine. Changes in haematological parameters were also observed. Silymarin-treated rats exhibited a significant reduction in paracetamol-induced liver injury, assessed according to AST and ALT examination, and also showed a positive effect on BUN, serum creatinine, and haematological parameters as well.