Vol. 12, Special Issue 7 (2023)

Author(s):
Om Prakash, Shakarlingam Gomathinayagam, TJ Harikrishnan, M Raman, Velayudham Pandiyan and P Azhahianambi

Abstract:
The ABC transporter, P-glycoprotein of parasitic nematodes is one of the reasons for the resistance development mechanism to different, classes of anthelmintic drugs. The gastrointestinal nematodes H. contortus is responsible for haemonchosis that causes economic loss in the sheep and goat farming industry. Present research work was conducted in the H. contortus of sheep and goats to evaluate the involvement of Permissible glycoprotein (Pgp 2/PgpA) in the susceptible and resistant population by using qPCR. In the present study, the result shows that the Pgp gene expression was elevated in resistance as compared with the susceptible population of H. contortus.