Vol. 12, Special Issue 8 (2023)

Author(s):
Esha Sinha, Khushboo Panwar, Venu Gorre, Ambika Arun, Sudhir Kumar Prajapati, Bhavani Puvvala, Sabita Behera, Raj Sahoo and Krishna J Patel

Abstract:
Coronaviruses are a diverse group of viruses known to infect a wide range of animal species, including mammals and birds. The spike glycoprotein plays a pivotal role in viral entry and host cell recognition, making it a key determinant of host specificity and pathogenicity. Understanding the relationship and variations in the spike glycoprotein among different animal species is crucial for elucidating the zoonotic potential and interspecies transmission dynamics of coronaviruses. In this comparative analysis, we investigate the spike glycoprotein sequences of various coronaviruses from diverse animal hosts. Through phylogenetic and sequence similarity analyses, we identify evolutionary relationships within the spike glycoprotein. Our findings shed light on the cross-species transmission potential and the adaptive mechanisms of coronaviruses, contributing to the broader understanding of emerging viral threats and guiding strategies for zoonotic disease surveillance and control.