Vol. 12, Special Issue 9 (2023)

Author(s):
Gandham Nagarjuna, Donga Durga Veera Hanuman, Banothu Anil Kumar, Bobilli Rajender, Yadala Ravi Kumar, KV Venkata Rao, Vemula Sravathi, Mohammed Shaz Murtuza and Laudya Naveen

Abstract:
In this study, the antioxidant properties of Murraya koenigii were investigated in the context of oxidative stress induced by sodium fluoride in sheep red blood cells. Erythrocytes are particularly susceptible to oxidative damage due to their high content of polyunsaturated fatty acids. The experiment involved a 24-hour incubation of red blood cells with sodium fluoride, with ascorbic acid and Murraya koenigii were investigated in the context of oxidative stress induced by sodium fluoride in sheep used as protective agents against oxidative stress. Assessment of oxidative stress was based on changes in SOD, GSH, and MDA levels in the RBCs. Treatment with both ascorbic acid and Murraya koenigii extract successfully restored these levels to normal, indicating their potential to mitigate oxidative stress induced by sodium fluoride in erythrocytes.