Vol. 12, Special Issue 9 (2023)

Author(s):
Sravathi Vemula, Jeevanalatha Mylaram, Ravikumar Yadala, Gopalareddy Alla, Mounika Kamishetti, Nagarjuna Gandham and Durga Veera Hanuman Donga

Abstract:
The purpose of this study was to assess the protective effects of Naringenin (NG) against cardiotoxicity induced by 5-Fluorouracil (5-FU) in Wistar rats. A total of 48 male rats, all of uniform size, were divided into four groups, each consisting of 12 animals. Group 1, designated as the control group, received normal saline (NS) orally (P/O). Group 2 served as the 5-FU toxic group and received intraperitoneal (IP) injections of 5-FU at a dose of 20 mg/kg body weight for the first 5 days. Group 3 received NG orally at a dose of 100 mg/kg body weight per day for 28 days, while Group 4 was injected IP with 5-FU and concurrently received NG orally for 28 days before being sacrificed on the 14^th and 28^th days of the experiment. The administration of NG significantly ameliorated lipid peroxidation (TBARS) and boostened increased levels of antioxidant concentration levels of glutathione (GSH) and superoxide (SOD) in group-4 rats along with mitigation of RBC abnormalities. In conclusion, the results of this study indicate that NG possesses significant potential in preventing 5-FU-induced cardiotoxicity through antioxidant properties.