Vol. 12, Special Issue 9 (2023)

Author(s):
J Venkatesh Yadav, T Ramanujadas, GV Sudhakar Rao and N Pazhanivel

Abstract:
Argyrophilic nucleolar organized region (AgNOR) stains proteins associated with the nucleolar organized region and corresponds to cell proliferation. AgNOR is widely distributed in the nucleus and is more abundant in malignant cells than in non-malignant cells. In this study, a total of 12 different tumor samples were collected and stained with AgNOR staining technology. The average AgNOR numbers in malignant and non-malignant cells and the distribution of AgNOR dots in the cells were calculated and compared. The number and distribution of AgNOR were higher in malignant tumors than in normal tumors. We believe that AgNOR staining is a simple, rapid and reliable method for assessing cell proliferation and malignancy.