Vol. 12, Special Issue 10 (2023)

Aim: The purpose of this study was to assess the effects of long-term Metformin administration on the rat liver's structure and functions.

Material and Methods: In this study, Twenty Wister rats were used in this investigation, and they were randomly split into two groups of ten each. The first group served as the control and the second group got metformin hydrochloride at a dose of 30 mg/kg body weight/day for a period of twenty one straight days. At the end of study period, all rats were sacrificed to analyze the hematological, biochemical and the path morphological changes observed in the liver of rats.

Conclusion: The outcomes showed that metformin produces significant liver dysfunctions in rats, which were supported by biochemical analyses and liver histology.