Vol. 12, Special Issue 10 (2023)

Author(s):
Manasa NS, Shilpa VT, Girish BC, Nagappa S Karabasanavar, Ravikumar P, Satheesha SP and Ravikumar BP

Abstract:
Cardiovascular diseases are a group of public health disorders involving pathology of heart and blood vessels, Development of animal models for such diseases to accurately imitate the illness and respond to infection in the same way that humans do is essential to explore better therapeutic modalities for clinical use. This idea could be supported by specific facts or concluded from similarities between the animal model and humans. Pigs, dogs, and lambs are frequently employed in translational experimental studies of cardiovascular disease. Pigs were chosen as a viable animal model for the human cardiovascular system because human research presents substantial scientific and ethical challenges. Although the pig and human hearts have similar coronary circulation and hemodynamics, human healthcare practices and instruments can be used on the pig to fully grasp the structure, function, and an excellent model for studying cardiovascular disorders. Pigs and humans share many characteristics, making them a suitable model for examining cardiovascular conditions.